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Production and characterization of a new monoclonal antibody, GR-ICOR-2, recognizing sarcomeric actin: analysis of the expression in the developing chick heart

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Production and characterization of a new monoclonal antibody GRICOR2 recognizing sarcomeric actin.pdf(3.91 MB)
Date
1994
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Authors
Fernández, J.E. ; Melguizo, C. ; Prados, J. ; Marchal, J.A. ; Alvarez, L. ; Aránega, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We produced and characterized a specific monoclonal antibody (mAB) designated GR-ICOR-2. This mAb recognizes sarcomeric actin molecules (43 kDa) and was used in an immunohistochemical analysis of staining pattems in Harnburger and Hamilton's stages 18, 22 and 25 (HH 18, 22 and 25) embryonic chick hearts. Staining showed a mainly cytoplasmic distrubition in three regions: the atrioventricular (AV) canal cushion tissue, the primitive ventricle, and conal crests. In addition, this mAb-cross-reacted with rabbit and human cardiac and skeletal muscle tissue; but not with smooth muscle tissue.
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Actin , Embryo
Citation
URI
http://hdl.handle.net/10201/18540
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Histology and histopathology Vol. 9, nº 4 (1994)
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