Publication: Polarized endocytic transport ,The roles of Rab11 and Rab11-FIPs in regulating cell polarity
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Date
2009
Authors
Jing, Jian ; Prekeris, Rytis
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Endocytic transport plays a vital role in the
establishment and maintenance of cell polarity. Many
studies have demonstrated that endosome-dependent
protein targeting is required for polarization of epithelial
cells and neurons. Endocytic transport regulates several
highly polarized cellular events, such as cell motility and
division. Rab11 GTPase has been shown to be a master
regulator of protein transport via recycling endosomes,
and many recent studies have focused on the molecular
machinery that mediates Rab11-dependent endocytic
protein transport in polarized cells. This mini-review
describes the recent advances in identifying and
characterizing the role of Rab11 and its effector proteins
that play important roles in polarized endocytic sorting
and transport.
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