Publication: Expression of mitotic kinases phospho-aurora
A and aurora B correlates with clinical and
pathological parameters in bladder neoplasms
Authors
Bufo, P. ; Sanguedolce, Francesca ; Tortorella, Simona ; Cormio, Luigi ; Carrieri, Giuseppe ; Pannone, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Aurora A and Aurora B are serine-threonine
kinase proteins which have both been implicated in
human carcinogenesis through development of
aneuploidy and chromosomal instability. The aim of the
study is to assess the correlation of both markers with
clinical and pathological parameters in patients with
bladder cancer of different grade and stage. A bladder
cancer cell line was assessed for Aurora A and Aurora B
expression by Western blotting. Furthermore, 85
consecutive cases of bladder neoplasms obtained by
transurethral resection were quantitatively and
qualitatively analysed by immunohistochemistry for
Phospho-Aurora A and Aurora B expression. All cases
were stratified in 4 groups according to intracellular
localization (nuclear, cytoplasmic) of both markers. The
association between each group and clinical and
pathological parameters was assessed by statistical
analysis. Higher expression of cytoplasmic PhosphoAurora
A correlated significantly with poor histological
differentiation (G3 vs. G1) and advanced stage (p<0.05);
there was also high significant correlation between
nuclear Aurora B and both grading (both G3 and G2 vs.
G1) and mitotic index (p<0.05). No statistically
significant association was found between protein levels
detected in tumour and sex or age (p>0.05). To our
knowledge, the present study is the first to highlight the
existence of a statistical association between such
markers and traditional prognostic factors in bladder
cancer. These findings indicate that Aurora A and B
could be involved in the tumorigenesis of bladder
cancer, thus providing a basis for a target therapy
approach by using specific anti-mitotic agents.
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