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Inherited epigenetic hallmarks of childhood obesity derived from prenatal exposure to obesogens

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dc.contributor.authorNúñez-Sánchez, María Á.
dc.contributor.authorJiménez-Méndez, Almudena
dc.contributor.authorSuárez Cortés, María
dc.contributor.authorMartínez-Sánchez, María A.
dc.contributor.authorSánchez-Solís de Querol, Manuel
dc.contributor.authorBlanco Carnero, José Eliseo
dc.contributor.authorRuiz Alcaraz, Antonio José
dc.contributor.authorRamos-Molina, Bruno
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.contributor.otherFacultad de Biología
dc.date.accessioned2026-01-13T11:29:46Z
dc.date.available2026-01-13T11:29:46Z
dc.date.copyright© 2023 by the authors
dc.date.issued2023-03-07
dc.description.abstractChildhood obesity has reached epidemic levels in developed countries and is becoming a major cause for concern in the developing world. The causes of childhood obesity are complex and multifactorial, involving the interaction between individual genetics and environmental and developmental factors. Among the environmental factors, there is a growing interest in understanding the possible relationship between the so-called environmental obesogens and the development of obesity in children. Exposure to these obesogens such as phthalates, bisphenol A, or parabens, has been identified as a promoter of obesity through different mechanisms such as the alteration of adipocyte development from mesenchymal progenitors, the interference with hormone receptors, and induced inflammation. However, less attention has been paid to the inheritance of epigenetic modifications due to maternal exposure to these compounds during pregnancy. Thus, the aim of this review is to summarize the current knowledge of epigenetic modifications due to maternal exposure to those obesogens during pregnancy as well as their potential implication on long-term obesity development in the offspring and transgenerational inheritance of epiphenotypes.
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dc.format.extent15
dc.identifier.citationInt. J. Environ. Res. Public Health 2023, 20, 4711
dc.identifier.doihttps://doi.org/10.3390/ijerph20064711
dc.identifier.eissn1660-4601
dc.identifier.issn1661-7827
dc.identifier.urihttp://hdl.handle.net/10201/186149
dc.languageeng
dc.publisherMDPI
dc.relationThis research was funded by the Fundación Séneca (grant number 22080/JLI/22) and by the Institute of Health “Carlos III” (ISCIII), co-funded by the Fondo Europeo de Desarrollo Regional FEDER(grant numberPI20/00505). M.A.M-S was supported by PFIS predoctoral fellowship from the ISCIII (F121/0003, ISCIII, Spain; co-funded by the Fondo Europeo de Desarrollo Regional- FEDER). B.R-M was supported by the “Miguel Servet Type I” program (CP19/00098, ISCIII, Spain; co-funded by the Fondo Europeo de Desarrollo Regional-FEDER).
dc.relation.publisherversionhttps://www.mdpi.com/1660-4601/20/6/4711
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectEpiphenotypes
dc.subjectNon-persistent organic pollutants
dc.subjectPersistent organic pollutants
dc.subjectInorganic arsenic
dc.subjectChildhood obesity
dc.subjectEndocrine disrupting chemicals
dc.subjectObesogen
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleInherited epigenetic hallmarks of childhood obesity derived from prenatal exposure to obesogens
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
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