Relationship between periodontal disease and preterm birth. A systematic review and meta-analysis

Montoya Carralero, José María; Ávila Villasmil, Rebeca; Sánchez Pérez, Arturo; Jornet García, Alfonso; Terrer Alonso, Enrique; Moya Villaescusa, María José

Publication:
Relationship between periodontal disease and preterm birth. A systematic review and meta-analysis

dc.contributor.author	Montoya Carralero, José María
dc.contributor.author	Ávila Villasmil, Rebeca
dc.contributor.author	Sánchez Pérez, Arturo
dc.contributor.author	Jornet García, Alfonso
dc.contributor.author	Terrer Alonso, Enrique
dc.contributor.author	Moya Villaescusa, María José
dc.contributor.department	Dermatología, Estomatología, Radiología y Medicina Física
dc.date.accessioned	2024-11-27T11:25:05Z
dc.date.available	2024-11-27T11:25:05Z
dc.date.issued	2024-11-01
dc.description	© 2024 Medicina Oral S.L. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published version of a Published Work that appeared in final form in Medicina Oral Patología Oral y Cirugía Bucal. To access the final edited and published work see https://doi.org/10.4317/medoral.26830
dc.description.abstract	Background: Periodontal disease (PD) is a chronic inflammatory disease of multifactorial origin that affects the supporting tissues of the tooth. According to WHO in 2022, severe periodontal disease will affect around 19% of the adult population worldwide. Its risk factors include the presence of periodontopathogenic bacteria in biofilm and the susceptibility of the host’s immune system, among others. Preterm birth is defined as birth occurring before 37 weeks of gestational age. It also has a multifactorial origin and it’s associated with risk factors such as intrauterine and extrauterine infections. There is a possibility that periodontal disease in pregnant women increases the risk of preterm birth through hematogenous pathways or the presence and intervention of inflammatory mediators. Material and Methods: Through a systematic review of existing scientific articles from 2014 to 2024, five randomized clinical trials were selected, including a total of 1984 pregnant patients diagnosed with periodontal disease. Half of these patients received non-surgical treatment, while the other half did not, aiming to evaluate a possible association between periodontal disease and/or its treatment and the occurrence of preterm birth. The risk of bias was assessed using the Cochrane “RoB 2” tool, and finally, a meta-analysis was conducted to compare the results obtained in the selected studies. Results: Four articles showed a trend favoring non-surgical periodontal treatment as a preventive measure for preterm birth. These articles accounted for 92.2% of the total weight, while the remaining 7.85% corresponded to the single article that did not favor the treatment. However, none of the articles showed statistically significant results. Conclusions: There is no demonstrated association between periodontal disease in pregnant women and the incidence of preterm birth. On the other hand, there is a slightly favorable trend towards non-surgical periodontal treatment during pregnancy as a measure to reduce the incidence of preterm birth, but it’s not statistically significant. To obtain a definitive answer, more randomized clinical trials following similar study and design parameters are needed.	es
dc.format	application/pdf	es
dc.format.extent	9	es
dc.identifier.citation	Medicina Oral Patología Oral y Cirugía Bucal, 2024, Vol. 29 (6). 2024 Nov 1;29 (6), pp. e857-865
dc.identifier.doi	https://doi.org/10.4317/medoral.26830
dc.identifier.issn	Print: 1698-4447
dc.identifier.issn	Electronic: 1698-6946
dc.identifier.uri	http://hdl.handle.net/10201/146801
dc.language	eng	es
dc.publisher	Medicina Oral S.L.	es
dc.relation	Sin financiación externa a la Universidad	es
dc.relation.ispartof	Grado en Odontología. Periodoncia (6339)	es
dc.relation.publisherversion	https://pmc.ncbi.nlm.nih.gov/articles/PMC11584963/
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Periodontal disease	es
dc.subject	Preterm birth
dc.subject	Periodontal treatment
dc.subject	Adverse pregnancy outcomes
dc.subject.other	CDU::5 - Ciencias puras y naturales	es
dc.title	Relationship between periodontal disease and preterm birth. A systematic review and meta-analysis	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es