Publication: Effects of chronic administration of either
ethanol or pentanol on rat duodenum morphology
Authors
Vaquera, J. ; Vaquera, A. ; Girbes, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The morphology of the rat duodenum after
chronic treatment with 15% (v/v) ethanol and 4% (v/v)
pentanol was studied. Male Wistar rats of experimental
groups were given ethanol and pentanol for 15 weeks
with food and fluid freely available. Ethanol-15% and
4% pentanol-fed rats showed a significantly reduced
fluid and food intake as compared with control rats. The
study of the mucosa indicated that the number of chronic
inflammatory infiltrating (mononuclear cells) and goblet
cells was higher in the groups of the ethanol- and
pentanol-fed rats than in the control group. There was an
increase in the thickness of the brush border in pentanolfed
rats. Intervillus adhesion was concurrently observed
in the pentanol-fed rats but not in the control or ethanolfed
rats. After ethanol feeding many of the villi
developed blebs at the apex of the villus or laterally on
its upper half. These blebs generally remained intact. In
contrast, after pentanol feeding no bleb formation was
appreciated. The intake of ethanol and other short chain
alcohols present in alcoholic beverages leads to mainfold
disturbances on the rat duodenum. These findings
suggest that the chronic ingestion of pentanol seems to
promote cellular changes but less important than those
observed after chronic ethanol ingestion.
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