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Inhibition of gentamicin-induced nephrotoxicity by lithium in rat

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dc.contributor.authorSamadian, T.es
dc.contributor.authorDehpour, A.R.es
dc.contributor.authorAmini, Sh.
dc.contributor.authorNouhnejad, P.
dc.date.accessioned2011-02-01T09:16:12Z
dc.date.available2011-02-01T09:16:12Z
dc.date.issued1993
dc.description.abstractDaily intraperitoneal injection of gentamicin in doses of 2,4 and 10 mglkglday for 5 consecutive days produced proximal tubular necrosis in male albino rats as assessed by ultrastructural findings from electron microscopic observations. With respect to nephrotoxicity, aminoglycoside antibiotics (AGs) have been shown to concentrate in the lysosomes of kidney proximal tubular cells to inhibit the activities of phospholipases A and C, including a phospholipidosis, characterized by the formation of myeloid bodies. It has been suggested that the nephrotoxicity of AGs is related to the extent of this phospholipidosis. The concurrent therapy of lithium in doses of 5 and 10 mEqIkglday, administered subcutaneously, 24 hours prior to gentamicin administration for the same period, proved effective in reducing the gentamicin-induced phospholipidosis in kidney as judged by reduction in lysosomal myeloid bodies to an amount of 26-45 percent. It is well known that lithium interferes with phosphatidylinositol turnover and reduces the cellular availability of myoinositol which is needed for the resynthesis of membrane poliphosphoinositides. Thus, the inhibitory effect of lithium on gentamicin-induced nephrotoxicity may be due to interference of lithium with phosphoinositide cycle.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18383
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAminoglycosideses
dc.subjectGentamicines
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleInhibition of gentamicin-induced nephrotoxicity by lithium in rates
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 8, nº 1 (1993)