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Biocompatibility of a HA/β-TCP/C scaffold as a pulp-capping agent for vital pulp treatment: an in vivo study in rat molars

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dc.contributor.authorGuerrero Gironés, Julia
dc.contributor.authorAlcaina Lorente, Antonio
dc.contributor.authorOrtiz Ruiz, Clara
dc.contributor.authorOrtiz Ruiz, Eduardo
dc.contributor.authorPecci Lloret, María P.
dc.contributor.authorOrtiz Ruiz, Antonio José
dc.contributor.authorRodríguez Lozano, Francisco Javier
dc.contributor.authorPecci Lloret, Miguel R.
dc.contributor.departmentDermatología, Estomatología, Radiología y Medicina Física
dc.date.accessioned2024-06-19T11:59:22Z
dc.date.available2024-06-19T11:59:22Z
dc.date.issued2021-04-08
dc.description© 2021 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published version of a Published Work that appeared in final form in International Journal of Environmental Research and Public Health. To access the final edited and published work see https://doi.org/10.3390/ijerph18083936
dc.description.abstractBioceramic materials possess desirable biological properties, highlighting their non-reactivity and osteoconductivity. Their use has been extended in vital pulp treatment. The purpose of this study was to evaluate and compare the effects of beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA), and collagen (C) scaffold with mineral trioxide aggregate (MTA) on the vital pulp of rat molars. Thirty-two molars of Sprague–Dawley rats underwent direct pulp capping with β-TCP/HA/C (n = 16) and MTA (n = 16). After 30 days, the following parameters were evaluated in the tested samples: the degree of pulp inflammation and pulp vitality, the presence of reparative dentin, the homogeneity of the odontoblastic layer, and the presence of pulp fibrosis. No statistically significant differences were observed between HA/β-TCP/C and MTA in terms of the degree of inflammation (p = 0.124). Significant differences were found in reparative dentin formation between the treatment groups (p = 0.0005). Dentin bridge formation was observed in the MTA-treated group. The local action of HA/β-TCP/C is similar to that of MTA when used as an agent for pulp vital treatment in terms of absence of inflammation and maintenance of pulp vitality, although there are significant differences between both materials regarding the formation of dentin bridges.es
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dc.format.extent9es
dc.identifier.citationInternational Journal of Environmental Research and Public Health, 2021, Vol. 18 (8), 3936
dc.identifier.doihttps://doi.org/10.3390/ijerph18083936
dc.identifier.issnElectronic: 1660-4601
dc.identifier.issnPrint: 1661-7827
dc.identifier.urihttp://hdl.handle.net/10201/142453
dc.languageenges
dc.publisherMDPIes
dc.relationSin financiación externa a la Universidades
dc.relation.publisherversionhttps://www.mdpi.com/1660-4601/18/8/3936
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBeta-tricalcium phosphatees
dc.subjectHydroxyapatitees
dc.subjectMineral trioxide aggregatees
dc.subjectVital pulp therapyes
dc.subjectScaffoldses
dc.titleBiocompatibility of a HA/β-TCP/C scaffold as a pulp-capping agent for vital pulp treatment: an in vivo study in rat molarses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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