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Blood-brain barrier disruption following brain injury: Implications for clinical practice

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dc.contributor.authorBai, Ruojing
dc.contributor.authorGe, Xintong
dc.date.accessioned2024-10-10T09:15:38Z
dc.date.available2024-10-10T09:15:38Z
dc.date.issued2024
dc.description.abstractThe blood-brain barrier (BBB) plays a critical role in regulating the exchange of substances between peripheral blood and the central nervous system and in maintaining the stability of the neurovascular unit in neurological diseases. To guide clinical treatment and basic research on BBB protection following brain injury, this manuscript reviews how BBB disruption develops and influences neural recovery after stroke and traumatic brain injury (TBI). By summarizing the pathological mechanisms of BBB damage, we underscore the critical role of promoting BBB repair in managing brain injury. We also emphasize the potential for personalized and precise therapeutic strategies and the need for continued research and innovation. From this, broadening insights into the mechanisms of BBB disruption and repair could pave the way for breakthroughs in the treatment of brain injury-related diseases.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.citationHistology and Histopathology Vol. 39, nº11 (2024)
dc.identifier.doihttps://doi.org/10.14670/HH-18-740
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/144850
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBlood-brain barrieres
dc.subjectPermeabilityes
dc.subjectStrokees
dc.subjectTraumatic brain injuryes
dc.subjectPathological mechanismses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleBlood-brain barrier disruption following brain injury: Implications for clinical practicees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.39,nº11 (2024)