Publication:
Prenatal corticosterone influences the trajectory of neuronal development, delaying or accelerating aspects of the Purkinje cell differentiation

Simple item page
dc.contributor.authorRugerio-Vargas, C.es
dc.contributor.authorRamírez-Escoto, M.es
dc.contributor.authorDelaRosa-Rugerio, C.
dc.contributor.authorRivas-Manzano, P.
dc.date.accessioned2012-05-21T12:10:50Z
dc.date.available2012-05-21T12:10:50Z
dc.date.issued2007
dc.description.abstractThe nervous system developmental programs proceed in orderly fashion following strict timetables. However, the mechanisms regulating developmental timing remain largely unknown. Increases or decreases in glucocorticoids in the fetal brain can be detrimental. We present evidence supporting that corticosterone forwards the migration of cerebellar granule neurons when applied acutely during pregnancy. This change in developmental tempo enhances dendritic growth of Purkinje neurons, increases the nuclear area, accelerates perinucleolar rosette appearance and decreases the development of Nissl bodies. Our observations thus support that forwarding the occurrence of developmental events does not always arrest neuronal growth, as some heterochronic developmental models imply. We suggest that prenatal glucocorticoids alter the trajectory of Purkinje neurons development soon after birth. These changes could represent a transient condition or could produce medium or long-term later consequences. More studies are needed to evaluate these intriguing possibilitieses
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/27630
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectPurkinje neuronses
dc.subjectPrenatal glucocorticoidses
dc.subject.other576 - Biología celular y subcelular. Citologíaes
dc.titlePrenatal corticosterone influences the trajectory of neuronal development, delaying or accelerating aspects of the Purkinje cell differentiationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Prenatal corticosterone influences the trajectory of neuronal development delaying or accelerating aspects of the Purkinje cell differentiation.pdf
Size:
2.5 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Histology and histopathology Vol.22, nº 9 (2007)