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Preliminary analysis of the association of TRPV1 to the formation of Marfan syndrome aneurysms

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dc.contributor.authorSoto, María Elena
dc.contributor.authorSoria Castro, Elizabeth
dc.contributor.authorGuarner Lans, Verónica
dc.contributor.authorMartínez Guzmán, Andrés
dc.contributor.authorMorales Marín, Cesar Amilcar
dc.contributor.authorMartínez Zavala, Karla Susana
dc.contributor.authorPérez Torres, Israel
dc.date.accessioned2022-10-26T15:46:25Z
dc.date.available2022-10-26T15:46:25Z
dc.date.issued2019
dc.description.abstractMarfan syndrome (MS) is an autosomal dominant disorder of connective tissue that is caused by mutations in the fibrillin-1 (FBN-1) gene that cause degeneration of the artery. It is accompanied by endothelial dysfunction. The potential transient receptor of the vanilloid subfamily 1 (TRPV1) ion channel plays an important role in endothelial vascular functioning. Here we determine the association of the presence TRPV1 in aortic aneurysm with dilation and dissection of the artery in MS patients. Histological sections of aortic aneurysm tissue obtained by the surgical procedure of Bentall and De Bono or David, were processed by immunohistochemistry with antibodies against ICAM, VCAM, iNOS, eNOS, TRPV1 and TNF- α and the immunolabelling area was determined. We also measured the NO 3- /NO 2- ratio in the aortic tissue. C-reactive protein and HDL in plasma were quantified. A significant increase in iNOS, TRPV1, VCAM (p≤0.05), NO 3- /NO 2- ratio (p=0.002) and a significant decrease in eNOS (p=0.04) and HDL in plasma (p=0.02) in the MS vs. the C group were found. Conclusion: TRPV1 is over-expressed in aortic tissue from MS patients and can be associated with increases in iNOS, VCAM and a decrease in eNOS. These changes might contribute to the progression and rupture of the thoracic aneurysm.es
dc.formatapplication/pdfes
dc.format.extent15es
dc.identifier.citationHistology and Histopathology Vol. 34, nº 12 (2019)
dc.identifier.doihttps://doi.org/10.14670/HH-18-127
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/124907
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMarfan syndromees
dc.subjectTRPV1es
dc.subjecteNOSes
dc.subjectiNOSes
dc.subjectThoracic aneurysmes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titlePreliminary analysis of the association of TRPV1 to the formation of Marfan syndrome aneurysmses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.34,nº12 (2019)