Publication: Low expression of FGF1 (Fibroblast growth
factor-1) in rat parasympathetic preganglionic neurons
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Date
2007
Authors
Saito, A. ; Okano, H. ; Bamba, H. ; Hisa, Y. ; Oomura, Y. ; Imamura, T. ; Tooyama, I.
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Fibroblast growth factor-1 (FGF1), a member
of the FGF family of growth factors, is localized in
cholinergic neurons where it has trophic activity. We
recently reported that cholinergic neurons in the dorsal
motor nucleus of the vagus (DMNV) contain little
FGF1, raising the possibility that FGF1 is not localized
to parasympathetic preganglionic cholinergic neurons.
To clarify this issue, we investigated the co-localization
of FGF1 with cholinergic neuron markers in the
Edinger-Westphal nucleus (EWN), salivatory nucleus,
DMNV, and sacral parasympathetic nucleus by double
immunofluorescence using antibodies to FGF1 and
choline acetyltransferase (ChAT). The neurons in the
EWN were devoid of FGF1. In the salivatory nucleus,
13% of ChAT-positive neurons were also positive for
FGF1. In the DMNV, only 8% of ChAT-positive neurons
contained FGF1, and in the sacral parasympathetic
nucleus, 18% of ChAT-positive neurons were FGF1-
positive. We also confirmed that a large number of
ChAT-positive motor neurons in the oculomotor nucleus,
facial nucleus, hypoglossal nucleus, and spinal motor
neurons contained FGF1. The results confirmed that
parasympathetic preganglionic neurons are largely
devoid of FGF1, which is a unique feature among
cholinergic neurons.
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