Publication: Nuclear diacylglycerol kinases: emerging downstream regulators in cell signaling networks
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Date
2007
Authors
Evangelisti, C. ; Bortul, R. ; FalĂ , F. ; Tabellini, G. ; Goto, K. ; Martelli, A.M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
There exists an active lipid metabolism in the
nucleus, which is regulated differentially from the lipid
metabolism taking place elsewhere in the cell. Evidence
has been accumulated that nuclear lipid metabolism is
closely involved in a variety of cell responses, including
proliferation, differentiation, and apoptosis. A
fundamental lipid second messenger which is generated
in the nucleus is diacylglycerol, that is mainly known for
its role as an activator of some protein kinase C
isoforms. Diacylglycerol kinases attenuate
diacylglycerol signaling by converting this lipid to
phosphatidic acid, which also has signaling functions.
Ten mammalian diacylglycerol kinase isoforms have
been cloned so far, and some of them are found also in
the nucleus, either as resident proteins or after migration
from cytoplasm in response to various agonists.
Experiments using cultured cells have demonstrated that
nuclear diacylglycerol kinases have prominent roles in
cell cycle regulation and differentiation. In this review,
the emerging roles played by diacylglycerol kinases in
the nucleus, such as the control of G1/S phase transition,
are discussed.
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