Publication: Histological evaluation of colonic anastomotic healing, during perioperative Capecitabine administration. Experimental study in rats
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Date
2007
Authors
Konstantinidis, H.D. ; Sioga, A.C. ; Economou, L. ; Mpallas, K.D. ; Demertzidis, C.I. ; Pissanidou, T.T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Background: Neoadjuvant chemotherapy is a
highly promising treatment modality for colorectal
cancer. One of the basic side effects of this method is the
possible impact on anastomotic healing. Capecitabine is
a tumor selective pro-drug of 5-fluorouracil, indicated
for the therapy of colorectal cancer. The aim of this
study is to estimate the effect of perioperative
Capecitabine administration on the colonic anastomotic
healing process, by evaluating histopathological
findings. Methods: We studied the effect of Capecitabine
on hand sutured colonic anastomosis in rats. Sixty
Wistar rats were randomized in two groups. In the study
group (n=30) Capecitabine was given p.o. in therapeutic
dose of 359 mg/kg, (2/3 of the mean toxic dose), 1 week
prior the anastomosis and throughout the study. In the
control group (n=30) placebo medication was
administrated. Both groups were further subdivided into
3 groups, each consisting of 10 animals. Rats of each
group were sacrificed on the 3rd, 7th and 14th
postoperative day, in both study and control groups.
Results: No negative impact on the healing process of
colonic anastomosis was found. Histological findings
indicated a more effective healing during the early
postoperative days, with lesser necrosis effects on the
anastomotic line for the study group, in comparison with
the control group. The median bursting pressure was
found to be significantly higher in the subdivision of the
study group sacrificed on the 3rd day, in comparison to respective control subdivision. Conclusion:
Perioperative administration of Capecitabine, as
neoadjuvant chemotherapy, does not impair the healing of colonic anastomosis in rats.
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