Publication: Peanut lectin-binding sites and mucins in benign and malignant colorectal tissues associated with schistomatosis
Loading...
Date
1998
Authors
Lin, M. ; Hanai, J. ; Gui, L.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
An immunohistochemical and histochemical
comparative study was carried out in benign and
malignant colorectal tissues with and without schistosomiasis.
This included a quantitative determination of
peanut lectin (PNA)-binding sites and proliferating cell
nuclear antigen (PCNA) expression and histochemical
detection of mucin changes. 133 cases were studied,
including 70 cases of colorectal carcinoma associated
with schistosomiasis (CCS) and 63 cases of colorectal
carcinoma without schistosomiasis (CC). Significant
differences were found in the type of mucin-containing
carcinomas (MC) between CCS and CC. 65% of nontumorous
mucosa adjacent to MC of the CCS group
expressed PNA-binding sites, significantly higher than
those of the MC in the CC group (31%). The nontumorous
mucosa in cases of MC of the CCS group also
showed a high percentage of sialomucin-predominant
secretion (69%, vs 38% in MC of the CC group).
Consistently, the presence of PNA-binding sites in MC
tumors of the CCS group was increased, compared with
that in the same subtype in the CC group (respectively
65% and 31% of strong positivity for PNA). However,
no differences in expression of PNA and mucin changes
were demonstrated in the surrounding mucosa and
tumorous tissues of non-mucin-containing carcinomas
(NMC) between CCS and CC. The expression of PCNA
was not different between CCS and CC and their
subtypes. Our findings suggest a close relationship
between mucin-containing colorectal carcinomas and
schistosomiasis japonica.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.