Publication: Murine embryonic stem cell in vitro differentiation: applications to the study of vascular development
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Date
2003
Authors
Feraud, O. ; Vittet, D.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The present review summarizes knowledge
accumulated during the last decade concerning in vitro
endothelial differentiation from embryonic stem (ES)
cells. There is now growing evidence that ES cells may
provide a powerful model system to determine the
cellular and molecular mechanisms of vascular
development. ES cells differentiate into the endothelial
lineage by successive maturation steps recapitulating in
vivo events observed in the embryo. Further maturation
of ES-derived embryoid bodies either in three
dimensional gels or in confrontation cultures with tumor
spheroids can also provide a model of physiological or
tumoral angiogenesis. The data obtained from
experimental in vitro differentiation of genetically
modified mouse ES cells highlight the potential and the
complementarity of this model system to in vivo gene
knock out studies. We also consider and discuss some of
the potential applications of ES cell technology in
vascular biology for future directions in basic research
and medicine, by manipulation of differentiation and the
generation of cell populations for analysis and
transplantation for therapeutic use.
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