Publication: Lysyl oxidases in mammalian development and certain pathological conditions
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Date
2009
Authors
Mäki, Joni M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Lysyl oxidase (LOX) catalyzes the oxidation
of the side chain of a peptidyl lysine converting specific
lysine and hydroxylysine residues of a–aminoadipic-d-
semialdehydes, which form covalent crosslinks in
collagens and elastin. Five different but closely related
lysyl oxidase isoenzymes have been identified to date,
and they seem to have overlapping functions in many
tissues. Modification of the extracellular matrix by lysyl
oxidases has been shown to be a critical contributor to
the development of various organs and certain
pathological conditions.
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Citation
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