Publication:
Particulate matter and temperature: increased risk of adverse clinical outcomes in patients with atrial fibrillation

Simple item page
dc.contributor.authorRivera-Caravaca, José Miguel
dc.contributor.authorRoldán Schilling, Vanessa
dc.contributor.authorVicente García, Vicente
dc.contributor.authorLip, Gregory YH
dc.contributor.authorMarín Ortuño, Francisco
dc.contributor.departmentEnfermería
dc.date.accessioned2024-02-07T09:46:25Z
dc.date.available2024-02-07T09:46:25Z
dc.date.issued2020
dc.description© 2020 Mayo Foundation for Medical Education and Research. This document is the Published version of a Published Work that appeared in final form in Mayo Clinic Proceedings. To access the final edited and published work see https://doi.org/10.1016/j.mayocp.2020.05.046
dc.description.abstractObjective: To test the hypothesis that particulate matter with an aerodynamic diameter of less than 10 mm (PM10) and temperature are associated with an increased risk of adverse clinical outcomes in patients with atrial fibrillation (AF) taking vitamin K antagonists (VKAs). Patients and Methods: We included patients with AF whose condition was stable while taking VKAs (international normalized ratio, 2.0 to 3.0) for 6 months seen in a tertiary hospital (recruitment from May 1, 2007, to December 1, 2007). During a median follow-up of 6.5 years (interquartile range, 4.3 to 7.9 years), ischemic strokes, major bleeding, adverse cardiovascular events, and mortality were recorded. From 2007 to 2016, data on average temperature and PM10 were compared with clinical outcomes. Results: The study group included 1361 patients (663 [48.7%] male; median age, 76 years [interquartile range, 71 to 81 years]). High PM10 and low temperatures were associated with higher risk of major bleeding (adjusted hazard ratio [aHR], 1.44; 95% CI, 1.22 to 1.70 and aHR, 1.03; 95% CI, 1.01 to 1.05, respectively) and mortality (aHR, 1.50; 95% CI, 1.34 to 1.69 and aHR, 1.04; 95% CI, 1.02 to 1.06, respectively); PM10 was also associated with ischemic stroke and temperature with cardiovascular events. The relative risk (RR) for cardiovascular events and mortality increased in months in the lower quartile of temperature (RR, 1.12; 95% CI, 1.04 to 1.21 and RR, 1.41; 95% CI, 1.15 to 1.74, respectively). Comparing seasons, there were higher risks of cardiovascular events in spring, autumn, and winter than in summer, whereas the risk of mortality increased only in winter. Conclusion: In patients with AF taking VKAs, high PM10 and low temperature were associated with increased risk of ischemic stroke and cardiovascular events, respectively. Both factors increased major bleeding and mortality risks, which were higher during colder months and seasons.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationMayo Clinic Proceedings, Volume 95, Issue 11, November 2020, Pages 2360-2369
dc.identifier.doihttps://doi.org/10.1016/j.mayocp.2020.05.046
dc.identifier.issnPrint: 0025-6196
dc.identifier.urihttp://hdl.handle.net/10201/138842
dc.languageenges
dc.publisherElsevier
dc.relationInstituto de Salud Carlos III (PI17/01375) y grupo CB16/11/00385 del CIBERCVes
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleParticulate matter and temperature: increased risk of adverse clinical outcomes in patients with atrial fibrillationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Particulate Matter and Temperature.pdf
Size:
561.67 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.26 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos