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The promoting effects of Grin2d expression in tumorigenesis and the aggressiveness of esophageal cancer

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dc.contributor.authorWang, Lin Lin
dc.contributor.authorLi, Jun
dc.contributor.authorXue, Hang
dc.contributor.authorZhang, Li
dc.contributor.authorYu, Da yong
dc.contributor.authorYang, Ning
dc.contributor.authorYun, Wen jing
dc.contributor.authorZhao, Ming Zhen
dc.contributor.authorZheng, Hua Chuan
dc.date.accessioned2024-05-10T09:10:20Z
dc.date.available2024-05-10T09:10:20Z
dc.date.issued2024
dc.description.abstractGrin2d is an ionotropic NMDA receptor, a subunit of glutamate-dependent, and a facilitator of cellular calcium influx in neuronal tissue. In this study, we found that Grin2d expression was higher in esophageal cancer than in normal mucosa at both the mRNA and protein level using RT-PCR, bioinformatics analysis, and western blotting (p<0.05). Grin2d mRNA expression was positively correlated with old age, white race, heavy weight, distal location, adenocarcinoma, cancer with Barrett’s lesion, or high-grade columnar dysplasia (p<0.05). The differential genes associated with Grin2d mRNA were involved in fat digestion and absorption, cholesterol metabolism, lipid transfer, lipoproteins, synaptic membranes, and ABC transporters (p<0.05). The Grin2d-related genes were classified into the following categories: metabolism of glycerolipids, galactose, and O-glycan, cell adhesion binding, actin binding, cadherin binding, the Hippo signaling pathway, cell-cell junctions, desmosomes, DNA-transcription activator binding, and skin development and differentiation (p<0.05). Grin2d immunoreactivity was positively correlated with distal metastasis and unfavorable overall survival in esophageal cancer (p<0.05). Grin2d overexpression promoted proliferation, migration, and invasion in esophageal cancer cells but blocked apoptosis (p<0.05) and increased the expression of PI3K, Akt and p-mTOR. Grin2d knockout caused the opposite effects. These findings indicated that upregulated Grin2d expression played an important role in esophageal carcinogenesis via the PI3K/Akt/mTOR pathway and might be a biological marker for aggressive tumor behavior and poor prognosis. Its silencing might represent a targeted therapy approach against esophageal cancer.es
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dc.format.extent12es
dc.identifier.citationHistology and Histopathology Vol. 39, nº5 (2024)
dc.identifier.doihttps://doi.org/10.14670/HH-18-674
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/141481
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectEsophageal canceres
dc.subjectGrin2des
dc.subjectBiological behaviorses
dc.subjectPrognosises
dc.subjectGene therapyes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleThe promoting effects of Grin2d expression in tumorigenesis and the aggressiveness of esophageal canceres
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.39, nº5 (2024)