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Exploring in the classroom the relationship between alcohol intake and behavioral disorders through an animal model

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dc.contributor.authorHernández García, Samanta
dc.contributor.authorGuerrero-Rubio, M. Alejandra
dc.contributor.authorHenarejos Escudero, Paula
dc.contributor.authorMartínez Rodríguez, Pedro
dc.contributor.authorGandía Herrero, Fernando
dc.contributor.departmentBioquímica y Biología Molecular Aes
dc.coverage.spatialUniversidad de Murciaes
dc.coverage.temporal2024es
dc.date.accessioned2025-05-06T06:57:22Z
dc.date.available2025-05-06T06:57:22Z
dc.date.issued2024-03-19
dc.description© 2024, TheAuthors. This manuscript version is made available under the CC-BY-NC 4.0 license http://creativecommons.org/licenses/by-nc/4.0/. This document is the Published version of a Published Work that appeared in final form in Biochemistry and Molecular Biology Education. To access the final edited and published work see https://doi.org/10.1002/bmb.21829es
dc.description.abstractAlcohol consumption has profound effects on behavior, such as impaired judg-ment, addiction or even death. It is estimated that alcohol contributes to around three million deaths worldwide, 13.5% of them in young people with ages between 20 and 39 years. Consequently, it is necessary to raise awareness among college and high school students of the risk related to alcohol drinking. The small nematode Caenorhabditis elegans is an animal widely used as amodel organism to study nearly all aspects of Biochemistry. It is a powerfultool to test the potential bioactivity and molecular mechanisms of natural com-pounds and drugs in vivo. Therefore, it is an interesting topic to include in an undergraduate course of Biotechnology, Biochemistry or Biology students among other scientific vocations. C. elegans is also used as a neurobiological model to evaluate substances´ neurotoxicity and behavioral effects. The pro-posed experiment introduces students to the handling of this preclinical modeland to the evaluation of behavioral alterations induced by chemicals in scien-tific research. The effects of different doses of ethanol on C. elegans behavior are studied using a versatile chemotaxis assay. This laboratory experiment issuitable for an undergraduate course. The practical session can be used in theglobal strategies of information and awareness of educational centres to miti-gate the impact of alcohol abuse among students, both in formal courses or inScience fairs or exhibitionses
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dc.format.extent6es
dc.identifier.citationBiochem Mol Biol Educ. 2024 52:474–479
dc.identifier.doihttps://doi.org/10.1002/bmb.21829
dc.identifier.issnPrint: 1470-8175
dc.identifier.issnElectronic: 1539-3429
dc.identifier.urihttp://hdl.handle.net/10201/153960
dc.languageenges
dc.publisherWiley, International Union of Biochemistry and Molecular Biology (IUBMB)
dc.relationThis work was supported by the Spanish Ministry of Science and Innovation, project PID2021-122896NB-I00 (MCI/AEI/1013039/501100011033/FEDER, UE). P. M.-R. holds a contract financed by Fundacion Séneca (Spain) (21587/FPI/21). P. H.-E. holds a contract financed by University of Murcia (Spain).es
dc.relation.ispartofPID2021‐122896NB‐I00 (MCI/AEI/1013039/501100011033/FEDER, UE)es
dc.relation.publisherversionhttps://iubmb.onlinelibrary.wiley.com/doi/10.1002/bmb.21829
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectAlcohol abusees
dc.subjectDrugs/pharmaceuticalses
dc.subjectBiotechnologyes
dc.subjectConsumer chemistryes
dc.subjectHands-on learninges
dc.subjectLaboratory instructiones
dc.subjectScientific practicees
dc.subjectToxicologyes
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::577 - Bioquímica. Biología molecular. Biofísicaes
dc.titleExploring in the classroom the relationship between alcohol intake and behavioral disorders through an animal modeles
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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relation.isAuthorOfPublication.latestForDiscoverydb7a1a52-fec7-48eb-91e0-abe5e715b483
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