Publication: Mechanisms of human skin cell motility
Authors
Li, W. ; Fan, J. ; Chen, M. ; Woodley, D.T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The extracellular matrix (ECM) in contact
with the cells and the soluble growth factors (GFs)
binding to their cell surface receptors are the two main
signals that directly regulate cell motility. Human
keratinocytes and dermal fibroblasts are two primary cell
types in skin that must undergo migration for skin
wounds to heal. In this cell migration, ECMs play an
“active” role by providing the cells with both focal
adhesions and a migration-initiating signal, even in the
absence of GFs. In contrast, GFs cannot initiate cell
migration in the absence of a pro-migratory ECM.
Rather, GFs play a “passive” role by enhancing the
ECM-initiated motility and giving the moving cells
directionality. Inside the cells, the initiation signal of the
ECM and the optimization signals of the GFs are
propagated by both overlapping and discrete signaling
networks. However, activation of no single signaling
pathway by itself is sufficient to replace the role of
ECMs or GFs. This review focuses on our current
understanding of both the individual and the combined
functions of ECMs and GFs in the control of skin cell
motility. An abbreviation of the terminologies used in
this article is provided.
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