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Transglutaminase 2 expression is significantly increased in cyclosporine-induced gingival overgrowth

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dc.contributor.authorAsioli, Sofia
dc.contributor.authorRighi, Alberto
dc.contributor.authorCardone, Pietro
dc.contributor.authorAimetti, Mario
dc.contributor.authorMaletta, Francesca
dc.contributor.authorCoda, Renato
dc.contributor.authorCarossa, Stefano
dc.contributor.authorNavone, Roberto
dc.contributor.authorCassoni, Paola
dc.date.accessioned2016-05-02T15:03:11Z
dc.date.available2016-05-02T15:03:11Z
dc.date.issued2011
dc.description.abstractCyclosporine A is a potent immunosuppressant used to prevent organ transplant rejection and treat various autoimmune diseases. However, cyclosporine A can also induce gingival overgrowth, which is characterized by increased extracellular matrix due to an altered balance between collagen synthesis and degradation. This study proposed to verify whether trans-glutaminase 2, an enzyme thought to be responsible for the assembly and remodelling of extracellular matrix, plays any role in the pathogenesis of cyclosporine A-induced gingival overgrowth. Cyclosporine A-induced gingival overgrowths were collected from 21 liver transplant patients and case-controlled with 20 non-hyperplastic gingival biopsies from healthy patients who had previous periodontal treatment. In both groups, the presence and tissue distribution of transglutaminase 2 were determined by immunohistochemistry and analyzed in comparison with the tissue morphology and expression of lymphocyte-related antigens (CD3 and CD20) and a vessel-related marker (CD34). Transglutaminase 2 expression showed a significant increase (2.6-fold) in the stromal component of cyclosporine A-treated patients compared with controls (p<0.001), which suggested that transglutaminase 2 had a role in the pathogenesis of the disease. Further studies should investigate the therapeutic effect of anti-transglutaminase 2 drugs (putrescine or 1,4-diamino-butane) in these patients.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/49496
dc.languageenges
dc.publisherF. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología.es
dc.relation.ispartofHistology and histopathology, Vol. 26, nº11 (2011)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectTransglutaminase 2es
dc.subjectCyclosporinees
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleTransglutaminase 2 expression is significantly increased in cyclosporine-induced gingival overgrowthes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26,nº11 (2011)