The α-melanocyte-stimulating hormone/melanocortin-1 receptor interaction: a driver of pleiotropic effects beyond pigmentation.

Martínez-Vicente, Idoya; Maresca, Vittoria; Herraiz Serrano, Cecilia María

Publication:
The α-melanocyte-stimulating hormone/melanocortin-1 receptor interaction: a driver of pleiotropic effects beyond pigmentation.

dc.contributor.author	Martínez-Vicente, Idoya
dc.contributor.author	Maresca, Vittoria
dc.contributor.author	Herraiz Serrano, Cecilia María
dc.contributor.department	Bioquímica y Biología Molecular B e Inmunología
dc.date.accessioned	2025-01-21T07:39:56Z
dc.date.available	2025-01-21T07:39:56Z
dc.date.issued	2021-04-21
dc.description	© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Accepted version of a Published Work that appeared in final form in Pigment Cell & Melanoma Research. To access the final edited and published work see https://doi.org/10.1111/pcmr.12980
dc.description.abstract	Melanocortin-1 Receptor (MC1R), when stimulated by alpha-melanocyte-stimulating hormone (α-MSH), is a driver of eumelanogenesis. Brown/black eumelanin is an effective filter against ultraviolet radiation (UVR) and is a scavenger of free radicals. Several polymorphic variants of MC1R are frequent in red-head people. These polymorphisms reduce the ability of MC1R to promote eumelanogenesis after its activation and spontaneous pheomelanogenesis take place. Since pheomelanin can act as an endogenous photosensitizer, people carrying MC1R polymorphisms are more susceptible to skin cancer. Here, we summarize current knowledge on the biology of MC1R beyond its ability to drive eumelanogenesis. We analyze its capacity to cope with oxidative insult and consequent DNA damage. We describe its ability to transduce through different pathways. We start from the canonical pathway, the cAMP/protein kinase A (PKA) pathway mainly involved in promoting eumelanogenesis, and protection from oxidative damage, and we then move on to describe more recent knowledge concerning ERK pathways, phosphoinositide 3-kinase (PI3K) pathway/AKT, and α-MSH/Peroxisome proliferators activated receptor-γ (PPAR-γ) connection. We describe MC1R polymorphic variants associated with melanoma risk which represent an open window of clinical relevance.
dc.format	application/pdf	es
dc.format.extent	14
dc.identifier.citation	Pigment Cell Melanoma Res. 2021 34:748–761
dc.identifier.doi	https://doi.org/10.1111/PCMR.12980
dc.identifier.issn	Print: 1755-1471
dc.identifier.issn	Electronic: 1755-148X
dc.identifier.uri	http://hdl.handle.net/10201/148881
dc.language	eng	es
dc.publisher	Wiley
dc.relation	I.M.‐V. is a predoctoral FPI fellow from the MINECO.	es
dc.relation.publisherversion	https://onlinelibrary.wiley.com/doi/10.1111/pcmr.12980
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	MC1R
dc.subject	Melanocytes
dc.subject	Melanogenesis
dc.subject	Melanoma cells
dc.subject	αMSH
dc.title	The α-melanocyte-stimulating hormone/melanocortin-1 receptor interaction: a driver of pleiotropic effects beyond pigmentation.	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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