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ATG7 immunohistochemical expression in malignant pleural mesothelioma. A preliminary report

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dc.contributor.authorRapisarda, Venerando
dc.contributor.authorBroggi, Giuseppe
dc.contributor.authorCaltabiano, Rosario
dc.contributor.authorLombardo, Claudia
dc.contributor.authorCastorina, Sergio
dc.contributor.authorTrovato, Angela
dc.contributor.authorLedda, Caterina
dc.contributor.authorFiletti, Veronica
dc.contributor.authorLoreto, Carla
dc.date.accessioned2023-02-03T10:28:36Z
dc.date.available2023-02-03T10:28:36Z
dc.date.issued2021
dc.description.abstractLiterature evidence has demonstrated a high incidence of asbestos-related malignant pleural mesothelioma (MPM) in a Sicilian town (Biancavilla, Italy), where fluoro-edenite (FE) fibers were discovered some decades ago. As ATG7 immunohistochemical analysis has been ascribed as a prognostic tool of improved survival, we decided to investigate, in MPM patients, exposed and not exposed to FE fibers, the immunohistochemical expression of this autophagyrelated protein named ATG7. We analyzed the correlation between ATG7 immunohistochemical level and clinicopathological parameters. Twenty MPM tissue samples, from patients with available clinical and follow-up data, were included in paraffin and processed for immunohistochemistry. The immunohistochemical results confirmed activation of the autophagic process in MPM. Densitometric and morphometric expressions of ATG7 were significantly increased in MPMs when compared to the control tissues. A significant association of a high level of ATG7 with increased survival was demonstrated, with a mean overall survival (OS) of 12.5 months for patients with high expression vs. a mean OS of 4.5 months for patients with low ATG7 expression. In addition, a significant correlation between ATG7 expression and the survival time of MPM patients was observed. This study represents a starting point to hypothesize the prognostic role of ATG7 which could be a reliable prognostic indicator in MPMes
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dc.format.extent8es
dc.identifier.citationHistology and Histopathology Vol. 36, nº12 (2021)
dc.identifier.doihttps://doi.org/10.14670/HH-18-396
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/128132
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMalignant Pleural Mesotheliomaes
dc.subjectAutophagyes
dc.subjectATG7es
dc.subjectImmunohistochemistryes
dc.subjectAsbestiform fiberses
dc.subjectEx vivo studyes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleATG7 immunohistochemical expression in malignant pleural mesothelioma. A preliminary reportes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.36,nº12 (2021)