Publication: The distribution of cholinergic
neurons in the human central nervous system
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Date
2000
Authors
Oda, Y. ; Nakanishi, I.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Choline acetyltransferase (ChAT), the
enzyme responsible for the biosynthesis of
acetylcholine, is presently the most specific marker for
identifying cholinergic neurons in the central and
peripheral nervous systems. The present article reviews
immunohistochemical and in situ hybridization studies
on the distribution of neurons ex pressing ChAT in the
human central nervous system. Neurons with both
immunoreactivity and in situ hybridization signals of
ChAT are observed in the basal forebrain (diagonal band
of Broca and nucleus basalis of Meynert), striatum
(caudate nucleus, putamen and nucleus accumbens),
cerebral cortex, mesopontine tegmental nuclei
(pedunculopontine tegmental nucleus, laterodorsal
tegmental nucleus and parabigeminal nucleus), cranial
motor nuclei and spinal motor neurons. The cerebral
cortex displays regional and laminal differences in the
distribution of neurons with ChAT. The medial seotal
nucleus and medial habenular nucleus contain
immunoreactive neurons for ChAT, which are devoid of
ChAT mRNA signals. This is probably because there is a
small number of cholinergic neurons with a low level of
ChAT gene expression in these nuclei of human.
Possible connections and speculated functions of these
neurons are briefly summarized.
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Citation
Histology and Histopathology, Vol. 15, n.º 3 (2000)
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