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Association between interleukin-10 gene polymorphisms and risk of oral carcinoma: A meta-analysis

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dc.contributor.authorLi, Fan
dc.contributor.authorXu, Xing
dc.contributor.authorXuan, Chao
dc.contributor.authorChen, Wan-Tao
dc.date.accessioned2022-12-14T15:58:47Z
dc.date.available2022-12-14T15:58:47Z
dc.date.issued2020
dc.description.abstractBackground. The single nucleotide polymorphisms (SNPs) of Interleukin-10 (IL-10) gene have been linked with the risk of oral carcinoma (OC) in a relatively small sample size. Our study aims to investigate the pooled associations by conducting a meta-analysis of published studies. Methods. PubMed, Web of Science and Google Scholar databases were searched to identify eligible studies published in English before October 2019. The odds ratio (OR) with a 95% confidence interval (CI) was used to assess association. The publication bias was detected by Begg's test. Sensitivity and cumulative analyses were performed to evaluate the stability of crude results. Results. The meta-analysis involved eight studies. Significant associations were certified between IL-10 gene -1082A/G polymorphism and susceptibility of OC for A vs. G (OR=1.817, 95% CI: 1.481-2.230), AA vs. GG (OR=3.436, 95% CI: 2.281-5.175), dominant genetic model (OR=2.913, 95% CI: 1.939-4.376), and recessive genetic model (OR=1.886, 95% CI: 1.372- 2.594) in overall population, East Asians and South Asians. In addition, the significant association between - 592A/C polymorphism of the gene and susceptibility of OC were detected in South Asians. Conclusions. The meta-analysis results support that the IL-10 gene -1082G allele is a risk factor for OC in East Asians and South Asians, and IL-10 gene -592C allele is a protective factor for the disease.es
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dc.format.extent8es
dc.identifier.citationHistology and Histopathology Vol. 35, nº11 (2020)
dc.identifier.doihttps://doi.org/10.14670/HH-18-275
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/126483
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectOral carcinomaes
dc.subjectIL-10es
dc.subjectPolymorphismes
dc.subjectMeta-analysises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleAssociation between interleukin-10 gene polymorphisms and risk of oral carcinoma: A meta-analysises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.35,nº11 (2020)