Publication:
Glucose transporter-1 expression and prognostic significance in pancreatic carcinogenesis

Simple item page
dc.contributor.authorPizzi, Saraes
dc.contributor.authorPorzionato, Andreaes
dc.contributor.authorPasquali, Claudio
dc.contributor.authorGuidolin, Diego
dc.contributor.authorSperti, Cosino
dc.contributor.authorFogar, Paola
dc.contributor.authorMacchi, Verónica
dc.contributor.authorDe Caro, Raffaelle
dc.contributor.authorPedrazzoli, Sergio
dc.contributor.authorParenti, Anna
dc.date.accessioned2013-09-25T08:06:40Z
dc.date.available2013-09-25T08:06:40Z
dc.date.issued2009
dc.description.abstractThe purposes of this study were to evaluate the prognostic significance of Glut-1 expression in patients with pancreatic ductal adenocarcinoma, and to analyse its expression in pancreatic intraepithelial neoplasias (PanIN) and non invasive intraductal papillary mucinous neoplasms (IPMN). Glut-1 expression was studied by immunohistochemistry in 60 pancreatic ductal adenocarcinomas and scored on a 4- point scale (1: <25%; 2: 25-50%; 3: 50-75%; 4: >75%). Relationships between Glut-1 score, histological grade and MIB-1 score were evaluated by the Spearman rank correlation test. Significant correlations were found between Glut-1 expression and histological grade (P<0.001) and MIB-1 score (P<0.01). Significant prognostic factors by univariate analysis were stage (P<0.0001), histological grade (P<0.001) and Glut-1 expression (P<0.005). Independent prognostic factors after multivariate analysis were stage (P<0.001) and Glut-1 expression (P<0.05), stratified as <50% and >50%. The correlation of Glut-1 score with histological grade and MIB-1 score indicated a higher glucose uptake in poorly differentiated and highly proliferative pancreatic cancer cells. Glut-1 immunohistochemical expression provides a useful prognostic factor in pancreatic ductal adenocarcinoma. Glut-1 expression was not found in PanINs 1 but in 27.8% and 43.8% of PanINs 2 and 3, and was not found in IPMNs with lowand moderate-grade dysplasia but in 60% of IPMNs with high-grade dysplasia, indicating Glut-1 involvement in a relatively early phase of pancreatic carcinogenesis.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/36078
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectPancreatic adenocarcinomaes
dc.subjectSurvivales
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleGlucose transporter-1 expression and prognostic significance in pancreatic carcinogenesises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Glucose transporter1 expression and prognostic significance in pancreatic carcinogenesis.pdf
Size:
18.46 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Histology and histopathology Vol.24, nº2 (2009)