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The biological role of Treg cells in ectopic endometrium homeostasis

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dc.contributor.authorBasta, Pawel
dc.contributor.authorKoper, Krzysztof
dc.contributor.authorKazmierczak, Wojciech
dc.contributor.authorWisniewski, Michal
dc.contributor.authorMakarewicz, Adrianna
dc.contributor.authorDutsch-Wicherek, Magdalena
dc.contributor.authorKojs, Zbigniew
dc.contributor.authorPopiela, Tadeusz J.
dc.contributor.authorSlusarz, Robert
dc.contributor.authorDubiel, Mariusz
dc.contributor.authorWicherek, Lukasz
dc.date.accessioned2019-10-11T14:48:22Z
dc.date.available2019-10-11T14:48:22Z
dc.date.issued2014
dc.description.abstractAlthough retrograde menstruation is observed in up to 90% of women, endometriosis actually develops in only15% of women. There is considerable evidence in the literature that ectopic endometrial cells are able to evade immune surveillance and that the immune response in the microenvironment of ectopic lesions is limited. Endometriosis develops when a deficiency in the local immune response has been generated, and progression of the disease is related to the intensity of this process. Over the last couple of decades it has been well known that T regulatory lymphocytes (Tregs) play a crucial role in controlling a variety of physiological and pathological immune responses. In this review we have focused on the physiological alteration of Treg cell infiltration into the endometrium during the reproductive processes of women. We discuss how a disturbance in Treg cell expansion is involved in generating such pathological processes as miscarriage and ectopic pregnancy development. We hypothesize about the role Treg cells might play in the survival of endometriosis foci in ectopic localization and in the evasion of such lesions from host immune surveillance.es
dc.formatapplication/pdfes
dc.format.extent17es
dc.identifier.citationHistology and Histopathology, vol. 29, nº 10, (2014)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/75529
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectEndometriosises
dc.subjectTreges
dc.subjectImmune tolerancees
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::618 - Ginecología. Obstetriciaes
dc.titleThe biological role of Treg cells in ectopic endometrium homeostasises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.29, nº10 (2014)