Publication: Clinical significance of FAK expression in human neoplasia
Authors
Chatzizacharias, Nikolaos A. ; Kouraklis, Gregory P. ; Theocharis, Stamatios E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Focal Adhesion Kinase is a 119-121 kDa
nonreceptor protein kinase widely expressed in various
tissues and cell types. Several studies showed that FAK
plays an important role in integrin signaling. Once
activated by integrin and non-integrin stimuli, it binds
and activates several other molecules, such as Src,
p130Cas, Grb2, PI3K and paxillin, thus promoting
signaling transduction. In normal cells FAK activity is
under constant regulation by mechanisms such as gene
amplification, alternative splicing and action of
phosphatases. On the contrary, in vitro studies showed
that in transformed cells unopposed FAK signaling
promoted cancer cells’ malignant characteristics. FAK
was held responsible for cancer cells’ uninhibited
proliferation, protection from apoptosis, invasion,
migration, adhesion and spreading, as well as tumor
angiogenesis. Several in vivo studies supported the
above observations and further correlated FAK
expression with various clinicopathological parameters
of several types of human malignancies. The purpose of
this article is a comprehensive review of the existing
data on FAK expression and signaling and their clinical
significance in human malignancy.
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