Publication: Extensive dynamic changes in the human transcriptome and its circadian organization during prolonged bed rest
Authors
Archer, Simon N. ; Möller-Levet, Carla ; Laing, Emma E. ; Derk-Jan, Dijk ; Bonmatí Carrión, María de los Ángeles
item.page.secondaryauthor
item.page.director
Publisher
Cell Press
publication.page.editor
publication.page.department
DOI
https://doi.org/10.1016/j.isci.2024.109331
item.page.type
info:eu-repo/semantics/article
Description
© 2024 The Authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/
This document is the Published Manuscript, version of a Published Work that appeared in final form in iScience. To access the final edited and published work see https://doi.org/10.1016/j.isci.2024.109331
Abstract
Physiological and molecular processes including the transcriptome change across the 24-h day, driven by molecular circadian clocks and behavioral and systemic factors. It is not known how the temporal organization of the human transcriptome responds to a long-lasting challenge. This may, however, provide insights into adaptation, disease, and recovery.
We investigated the human 24-h time series transcriptome in 20 individuals during a 90-day constant bed rest protocol. We show that the protocol affected 91% of the transcriptome with 76% of the transcriptome still affected after 10 days of recovery. Dimensionality-reduction approaches revealed that many affected transcripts were associated with mRNA translation and immune function. The number, amplitude, and phase of rhythmic transcripts, including clock genes, varied significantly across the challenge.
These findings of long-lasting changes in the temporal organization of the transcriptome have implications for understanding the mechanisms underlying health consequences of conditions such as microgravity and bed rest.
publication.page.subject
Citation
iScience, Vol. 27, Issue 3, 2024 : 109331
item.page.embargo
Collections
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by/4.0/