Publication: The relationship between mucin phenotype and
clinicopathological factors, proliferative activity
and p53 expression in gastric hyperplastic polyps
Authors
Li, Juan ; Wu, Li-Hua ; Shi, Yan ; Li, Hua-Min ; Song, Mei-Yue ; Jiao, Yu-Fei
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Aims: Gastric hyperplastic polyps (GHPs)
are the most common polypoid lesion of the stomach,
and their malignant potential has been demonstrated. In
the present study, we evaluated the mucin phenotypes of
GHPs and investigated the relationships among mucin
phenotypes and clinical-pathological factors,
proliferative activity and p53 expression in GHPs.
Methods: The CD10, MUC2, MUC5AC and MUC6
expression patterns of 238 GHPs were examined by
immunohistochemical staining. The GHP mucin
phenotypes were divided into 4 subtypes: the gastric
mucin phenotype (G-type), the intestinal mucin
phenotype (I-type), the mixed or gastrointestinal mucin
phenotype (GI-type) and the unclassified mucin
phenotype (U-type). Results: The G and GI types were
observed in 58% and 42% of the GHPs, respectively.
However, no I or U type GHPs were found in the present
study. The GI type was more common in lesions with
dysplasia or carcinoma than in polyps without dysplasia
or carcinoma (P<0.001). P53-positivity rate and high
index of Ki-67 tumors were significantly more common
in the GI-type than in the G-type polyps (P<0.001).
Conclusions: The mucin phenotype may serve as a
useful marker for the malignant potential of GHPs, and
GI-type GHPs should be considered to be a lesion with
malignant potential.
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Citation
Histology and Histopathology, vol. 29, nº 3 (2014)
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