Publication:
Elevated cathepsin K potentiates metastasis of epithelial ovarian cancer

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dc.contributor.authorFan, Xiujie
dc.contributor.authorWang, Chongjuan
dc.contributor.authorSong, Xianhui
dc.contributor.authorLiu, Huaqing
dc.contributor.authorLi, Xue
dc.contributor.authorZhang, Yuanfang
dc.date.accessioned2022-05-06T11:52:28Z
dc.date.available2022-05-06T11:52:28Z
dc.date.issued2018
dc.description.abstractCathepsin K, or CTSK, has been found to be involved in the peritoneal metastasis of ovarian carcinoma. However, the expression and clinicopathological significance of CTSK remains unknown in epithelial ovarian cancer (EOC). The aim of the present study was to investigate the expression of CTSK and its clinicopathological significance in EOC. TSK expression was evaluated using immunohistochemistry in EOC tissue microarray. The expression of CTSK in EOC was displayed to be markedly higher than that of adjacent normal control. In addition, CSTK expression was shown to be remarkably associated with metastases and inferior overall prognosis of EOC. In vitro, Knock-down of CTSD was exhibited to be able to suppress migration and invasion in EOC cell lines OV2008 but not proliferation in OV-2008. Together, our data showed that elevated CTSD in EOC can potentiate the metastasis of EOC cells, suggesting that targeting CTSD might be used as a novel therapeutic target for EOC.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationHistology and Histopathology, Vol.33, nÂş7, (2018)
dc.identifier.doiDOI: 10.14670/HH-11-960
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/119655
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCathepsin Kes
dc.subjectEpithelial ovarian canceres
dc.subjectMigrationes
dc.subjectInvasiones
dc.subjectPrognosises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleElevated cathepsin K potentiates metastasis of epithelial ovarian canceres
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.33, nÂş7 (2018)