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High Annexin A10 expression is correlated with poor prognosis in pancreatic ductal adenocarcinoma

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dc.contributor.authorIshikawa, Akira
dc.contributor.authorKuraoka, Kazuya
dc.contributor.authorZaitsu, Junichi
dc.contributor.authorSaito, Akihisa
dc.contributor.authorYamaguch, Atsushi
dc.contributor.authorKuwai, Toshio
dc.contributor.authorSudo, Takeshi
dc.contributor.authorHadano, Naoto
dc.contributor.authorTashiro, Hirotaka
dc.contributor.authorTaniyama, Kiyomi
dc.contributor.authorYasui, Wataru
dc.date.accessioned2023-02-14T09:40:13Z
dc.date.available2023-02-14T09:40:13Z
dc.date.issued2022
dc.description.abstractPancreatic ductal adenocarcinoma (PDAC) is the third-leading cause of cancer-related death. Owing to its poor prognosis, new molecular biomarkers for PDAC are needed. Annexin A10 (ANXA10) is a calcium- /phospholipid-binding protein belonging to the annexin family of proteins. ANXA10 is not only associated with gastric phenotypes, but also acts an independent prognostic factor in several cancers. However, the role of ANXA10 in PDAC remains unknown. Therefore, we examined the relationship between ANXA10 and the prognosis of PDAC. We analyzed the expression of ANXA10 using data from public databases, and performed immunohistochemistry analysis for 81 PDAC cases. We then investigated the relationship between ANXA10 expression and clinicopathological features. ANXA10 was detected in 47 of 81 PDAC cases (58%). High expression of ANXA10 was significantly related to poor overall survival (OS; p=0.011). Univariate analysis of OS revealed three prognostic parameters: tumor grade (p=0.046), perineural invasion (p=0.017), and ANXA10 expression (p=0.012). Multivariate analysis indicated that ANXA10 expression (p<0.01) alone was a prognostic factor in PDAC cases. Our findings suggest that ANXA10 expression is an independent prognostic factor in PDAC cases and shows promise as a new biomarker in PDAC.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationHistology and Histopathology Vol. 37, nº3 (2022)
dc.identifier.doihttps://doi.org/ 10.14670/HH-18-397
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/128426
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAnnexin A10es
dc.subjectPancreatic canceres
dc.subjectBiomarkeres
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleHigh Annexin A10 expression is correlated with poor prognosis in pancreatic ductal adenocarcinomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.37, nº3 (2022)