Publication: Ultrastructural changes in the gracile nucleus of the spontaneously diabetic BB rat
Authors
Tay, S.S.W. ; Wong, W. C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The present study describes the structural
changes in the gracile nucleus of the spontaneously
diabetic BB rat. At 3-7 days post-diabetes, axons,
axon terminals and dendrites showed electron-dense
degeneration. Degenerating axons were characterized
by swollen mitochondria, vacuolation, accumulation
of glycogen granules, tubulovesicular elements,
neurofilaments and dense lamellar bodies. Degenerating
axon terminals consisted of an electron-dense cytoplasm
containing swollen mitochondria, vacuoles and
clustering of synaptic vesicles. These axon terminals
made synaptic contacts with cell somata, dendrites and
other axon terminals. Degenerating dendrites were
postsynaptic to normal as well as degenerating axon
terminals. At 1-3 months post-diabetes, degenerating
electron-dense axons. axon terminals and dendrites
were widely scattered in the neuropil. Macrophages
containing degenerating electron-dense debris were
also present. At 6 months post-diabetes, the freshly
degenerating neurona1 elements encountered were
similar to those observed at 3-7 days. However, there were more degenerating profiles at 6 months postdiabetes
compared to the earlier time intervals.
Terminally degenerating axons were vacuolated and
their axoplasm appeared amorphous. It is concluded
that degenerative changes occur in the gracile nucleus
of the spontaneously diabetic BB rat.
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