Publication: Expression of galectin-l and -3 and of accessible binding sites during murine hair cycle
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Date
2000
Authors
Wollina, U. ; Lange, D. ; Paus, R. ; Burchert, M. ; Gabius, H.J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Although protein-carbohydrate interactions
are supposed to play key roles in cell adhesion,
signalling and growth control. Their exact role in skin
physiology has only recently been investigated. The
endogenous lectins galectin-l and galectin-3 have been
identified in skin including hair follicles. Here, we
analyzed the expression and distribution of these
galectins and their binding sites in C57BL/6 mice during
hair cycle. The expression of galectin-l and galectin-3
binding sites was found to be predominantly hair cycledependent
showing some overlapping to the expression
of galectin-l and -3. The outer root sheath (ORS)
expressed galectin-l binding sites during anagen IV to
V1 and in early catagen, whereas galectin-l was
expressed from early anagen to late catagen. The ORS
expressed galectin-3 binding sites during catagen
transition corresponding to a galectin-3 expression
during anagen V and catagen. The innermost layer of the
ORS expressed galectin-3 binding sites during anagen
V1 until catagen VIII, but galectin-3 during anagen I11 to
IV and catagen. The inner root sheath (IRS) expressed
galectin-3 binding sites only in anagen IV but missed
expression of any of the two galectins. The matrix cells
expressed galectin-3 binding sites in catagen 11-111 as
well as galectin-3 during anagen V to catagen IV. The
present study provides the first evidence for a cyclerelated
expression of both galectin-l and -3 and their
binding sites during murine hair cycle.
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