Publication: Immune signals in the context of secondary osteoporosis
Authors
Okada, Y. ; Tanaka, Y.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Bone homeostasis is maintained by a balance
between bone resorption by osteoclasts and bone
formation by osteoblasts, and alterations in bone
metabolism can lead to diseases such as osteoporosis.
Inter-cellular and intra-cellular signaling, originating
from the immune system, the largest source of cellderived
regulatory signals, are involved in these
processes. Immune-competent cells such as
macrophages and lymphocytes deliver cell-cell signaling
through soluble factors such as cytokines and through
direct contact with the cells. Such immunological signals
to the bone are transmitted primarily through osteoblasts
or direct stimulation of osteoclasts to induce osteoclast
maturation or bone resorption, which may in turn lead to
the disequilibrium of bone metabolism. Inflammatory
diseases such as rheumatoid arthritis are good examples
of such a process, in which immunological signals play a
central role in the pathogenesis of the accompanying
secondary osteoporosis. We will achieve a better
understanding of the pathogenesis of bone metabolism in
osteoporosis through immune signaling, and thereby
develop improved therapeutic strategies for these
conditions.
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Citation
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