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Lineage-specific gene radiations underlie the evolution of novel betalain pigmentation in Caryophyllales

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dc.contributor.authorBrockington, Samuel F.
dc.contributor.authorYang, Ya
dc.contributor.authorCovshoff, Sarah
dc.contributor.authorHibberd, Julián M.
dc.contributor.authorSage, Rowan F.
dc.contributor.authorWong, Gane K. S.
dc.contributor.authorMoore, Michael J.
dc.contributor.authorSmith, Stephen A.
dc.contributor.authorGandía Herrero, Fernando
dc.contributor.departmentBioquímica y Biología Molecular "A"es
dc.date.accessioned2025-06-23T10:08:35Z
dc.date.available2025-06-23T10:08:35Z
dc.date.issued2015-05-13
dc.description© 2015, The Authors. © 2015 New Phytologist Trust. This manuscript version is made available under the CC-BY-NC-ND 4.0. license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Published version of a Published Work that appeared in final form in New Phytologist. To access the final edited and published work see https://doi.org/10.1111/nph.13441es
dc.description.abstractBetalain pigments are unique to the Caryophyllales and structurally and biosynthetically dis-tinct from anthocyanins. Two key enzymes within the betalain synthesis pathway have beenidentified: 4,5-dioxygenase (DODA) that catalyzes the formation of betalamic acid andCYP76AD1, a cytochrome P450 gene that catalyzes the formation of cyclo-DOPA. We performed phylogenetic analyses to reveal the evolutionary history of the DODA andCYP76AD1 lineages and in the context of an ancestral reconstruction of pigment states weexplored the evolution of these genes in relation to the complex evolution of pigments inCaryophylalles. Duplications within the CYP76AD1 and DODA lineages arose just before the origin of beta-lain pigmentation in the core Caryophyllales. The duplications gave rise to DODA-a andCYP76AD1-a isoforms that appear specific to betalain synthesis. Both betalain-specific isoformswere then lost or downregulated in the anthocyanic Molluginaceae and Caryophyllaceae. Our findings suggest a single origin of the betalain synthesis pathway, with neofunctionaliza-tion following gene duplications in the CYP76AD1 and DODA lineages. Loss of DODA-a andCYP76AD1-a in anthocyanic taxa suggests that betalain pigmentation has been lost twice inCaryophyllales, and exclusion of betalain pigments from anthocyanic taxa is mediated throughgene loss or downregulation. [Correction added after online publication 13 May 2015: in thelast two paragraphs of the Summary the gene name CYP761A was changed to CYP76AD1.]es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.citationNew Phytologist (2015) 207: 1170–1180
dc.identifier.doihttps://doi.org/10.1111/nph.13441
dc.identifier.issnPrint: 0028-646X
dc.identifier.issnElectronic: 1469-8137
dc.identifier.urihttp://hdl.handle.net/10201/156560
dc.languageenges
dc.publisherWiley
dc.relationThis work was supported by a National Science Foundation award (grant numbers DEB 1354048 and DEB 1352907) to S.F.B., M.J.M. and S.A.S., and a NERC Independent Research Fellowship to S.F.B. The 1000 Plants (1KP) initiative, led by G.K.S.W., is funded by the Alberta Ministry of Enterprise and Advanced Education, Alberta Innovates Technology Futures (AITF), Innovates Centre of Research Excellence (iCORE), Musea Ventures and BGIShenzhen.es
dc.relation.publisherversionhttps://nph.onlinelibrary.wiley.com/doi/10.1111/nph.13441
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAnthocyanines
dc.subjectBetalainses
dc.subjectCaryophyllaleses
dc.subjectLineage-specific geneses
dc.subjectPigmentationes
dc.subjectTaxonomically restricted geneses
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::577 - Bioquímica. Biología molecular. Biofísicaes
dc.titleLineage-specific gene radiations underlie the evolution of novel betalain pigmentation in Caryophyllaleses
dc.typeinfo:eu-repo/semantics/articlees
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relation.isAuthorOfPublication.latestForDiscoverydb7a1a52-fec7-48eb-91e0-abe5e715b483
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