Publication: The two faces of the Integrated Stress Response in cancer progression and therapeutic strategies
Authors
Licari, Eugenia ; Falletta, Paola ; Sánchez del Campo Ferrer, Luis
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.biocel.2021.106059
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info:eu-repo/semantics/article
Description
©2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in The International Journal of Biochemistry & Cell Biology. To access the final edited and published work see https://doi.org/10.1016/j.biocel.2021.106059
Abstract
In recent years considerable progress has been made in identifying the impact of mRNA translation in tumour progression. Cancer cells hijack the pre-existing translation machinery to thrive under the adverse conditions originating from intrinsic oncogenic programs, that increase their energetic demand, and from the hostile microenvironment. A key translation program frequently dysregulated in cancer is the Integrated Stress Response, that reprograms translation by attenuating global protein synthesis to decrease metabolic demand while increasing translation of specific mRNAs that support survival, migration, immune escape. In this review we provide an overview of the Integrated Stress Response, emphasise its dual role during tumorigenesis and cancer progression, and highlight the therapeutic strategies available to target it.
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Citation
The International Journal of Biochemistry & Cell Biology, Volumen: 139 , año: 2021
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/