Publication: Wnt signaling in physiological and pathological bone formation
Authors
Tan, Zhenya ; Ding, Na ; Lu, Haimei ; Kessler, John A. ; Kan, Lixin
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-18-062
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info:eu-repo/semantics/article
Description
Abstract
Wnt signaling, canonical or non-canonical,
plays conserved roles in numerous physiological and
pathological processes. However, it is well beyond the
scope of this review to cover all functional aspects of
Wnt signaling in different contexts at reasonable depth;
therefore this review intends to cover only the roles of
Wnt signaling in bone biology; more specifically, we
intend to first update the roles of Wnt signaling in
physiological bone process, including in osteogenesis
and chondrogenesis, since recent years have witnessed
tremendous progressions in this area, and then we seek
to extend our understanding to the pathological bone
process, especially to the heterotopic ossification (HO),
even though the understanding of Wnt signaling in HO
has been limited. We then further clarify the potential
crosstalking between Wnt and other conserved signaling
pathways, including FGF, GPCR and Hif1α pathways.
Overall, our goal is to update the progressions, identify
the general theme and the knowledge gaps and discuss
the potential promising avenue for future applications in
HO prevention and treatment.
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Citation
Histology and Histopathology, Vol.34, nº4, (2019)
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