Publication: Expression of parathyroid hormone-related protein (PTHrP) in parathyroid tissue under normal and pathological conditions
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Date
2002
Authors
Kitazawa, R. ; Kitazawa, S. ; Maeda, S. ; Kobayashi, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Parathyroid hormone-related protein
(PTHrP), a factor responsible for malignancy associated
hypercalcemia, plays a physiological roles such as bone
development and placental calcium transport. The
expression of PTHrP in adult human parathyroid tissues
under normal and pathological conditions was analyzed.
By immunohistochemistry, PTHrP expression was
detected in 86% of normal parathyroid (12/14 cases),
74% of adenomas (14/19) and 89% of hyperplasia
secondary to chronic renal failure (16/18). PTHrP
protein was observed mainly in the cytoplasm of oxyphil
cells, consistent with the localization of its mRNA
demonstrated by in situ hybridization. The rate of
PTHrP-positive cells was higher in areas consisting of
oxyphil cells than in those of non-oxyphil cells,
regardless of whether the parathyroid was normal or
pathological. In the normal parathyroid, an age-related
increase in PTHrP expression was observed with a
relative increase in oxyphil cells, reflecting aging and
deterioration of parathyroid tissue. In adenoma, cases
with a predominance of oxyphil cells expressed PTHrP,
whereas clear cell adenoma did not. In secondary
hyperplasia, the rate of PTHrP-expressing cells was
higher than in normal parathyroid or adenoma, with
varying levels of expression among nodules. We
speculate that PTHrP could act through the paracrine/
autocrine mechanism to regulate proliferation and
d i fferentiation of normal and neoplastic parathyroid
cells.
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