Publication:
Nestin expression in normal adrenal gland and adrenocortical tumors

Simple item page
dc.contributor.authorToti, P.es
dc.contributor.authorRegoli, M.es
dc.contributor.authorNesi, G.
dc.contributor.authorOcchini, R.
dc.contributor.authorBartolommei, S.
dc.contributor.authorFonzi, L.
dc.contributor.authorBertelli, E.
dc.date.accessioned2011-06-30T12:01:08Z
dc.date.available2011-06-30T12:01:08Z
dc.date.issued2005
dc.description.abstractHuman adrenocortical cells have been shown to express cytokeratins and vimentin. Nestin is an intermediate filament protein that is mainly expressed in the developing nervous system and that has been recently reported in rat adrenal gland as well. Using immunohistochemical and biochemical approaches, the present study demonstrates that nestin is constantly expressed in situ in the cortex of normal human adrenal glands. Nestin expressing cells were prevalently located in the zona reticularis but some positive cells could be spotted in the zona fasciculata as well. Moreover, patches of nestin-positive cells have been constantly detected on sections of cortical adenomas. In contrast, adrenal carcinomas displayed a variable number of nestin-immunoreactive cells that in some cases were virtually absent. Samples of renal clear cell carcinoma metastasis in the adrenals were also examined which did not show nestin-immunoreactivity. We propose that a positive nestin-immunoreaction could be useful in differential diagnosis of clear cell tumors in adrenal glands.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22542
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectNestines
dc.subjectAdrenal glandes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleNestin expression in normal adrenal gland and adrenocortical tumorses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Nestin expression in normal.pdf
Size:
2.64 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Histology and histopathology Vol.20, nº 4 (2005)