Publication: The retinoblastoma gene family and its role in proliferation, differentiation and development
Loading...
Date
1996
Authors
De Luca, A. ; Esposito, V. ; Baldi, A. ; Giordano, A.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The retinoblastoma gene family is composed
of three members: the retinoblastoma gene, one of the
most well studied tumor suppressor genes and two
related proteins, p107 and pRb2lp130. These three
proteins share many structural and functional features
and play a fundamental role in growth control. Intense
investieation of these moteins has identified a series of U similar cell-cycle regulators and transcription factors
with which they interact. Although the precise function
of the retinoblastoma gene product and its relatives
remains unknown, recent data suggests that they play
parallel roles in controlling cell cycle progression and
promoting cellular differentiation. In this review, we will
attempt to clarify some of the molecular mechanisms by
which these three related proteins cooperate to control
cellular proliferation and differentiation.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.