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PLEKHG2 and the PLEKHG family: Linking Rho family GTPases to neural development and disorders

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dc.contributor
dc.contributor.authorSato Katsuya
dc.contributor.authorNishikawa Masashi
dc.contributor.authorNagata Koh-ichi
dc.contributor.authorUeda Hiroshi
dc.contributor.departmentBiología Celular e Histología
dc.date.accessioned2025-10-17T11:42:44Z
dc.date.available2025-10-17T11:42:44Z
dc.date.issued2025
dc.description.abstractRho family small GTPases (Rho GTPases) are key regulators of cellular morphology, primarily through their control of the actin cytoskeleton. They play crucial roles in various cellular processes, including cell division, adhesion, and migration. The activity of Rho GTPases is tightly regulated by specific guanine nucleotide exchange factors (GEFs), which facilitate the exchange of GDP for GTP, thereby activating the GTPases. In the human genome, RhoGEFs are categorized into two major families: the DOCK family, comprising 11 members characterized by dedicator of cytokinesis (DOCK) homology regions, and the Dbl family, consisting of 64 members that contain a diffuse B-cell lymphoma (Dbl) homology domain. This review focuses on the pleckstrin homology and RhoGEF domain containing G (PLEKHG) family within the Dbl family of RhoGEFs, which remains largely un-characterized. We summarize their structure and function, with a particular emphasis on PLEKHG2, discussing its regulatory mechanisms, interactions with various molecules, and its involvement in neural functions
dc.formatapplication/pdf
dc.format.extent13
dc.identifier.citationHistology and Histopathology, volúmen 40, nº 10 (2025)
dc.identifier.doihttps://doi.org/10.14670/HH-18-921
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/167411
dc.languageeng
dc.publisherUniversidad de Murcia, Departamento de Histología e Histopatología
dc.relationSin financiación externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectRhoGEF
dc.subjectPLEKHG family
dc.subjectRho GTPases
dc.subjectNeurodevelopmental
dc.subjectNeurological disorders
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titlePLEKHG2 and the PLEKHG family: Linking Rho family GTPases to neural development and disorders
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
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Histology and histopathology Vol.40,nº10 (2025)