Publication: Adrenomedullin regulates club cell recovery following lung epithelial injury
Authors
García-Sanmartín, Josune ; Larrayoz, Ignacio M. ; Martínez, Alfredo
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-704
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info:eu-repo/semantics/article
Description
Abstract
The equilibrium between lung epithelium
damage and recovery in the context of chronic injury is
at the basis of numerous lung diseases, including lung
cancer and COPD. Understanding the contribution of
growth factors and other molecular intermediates to this
crosstalk may help in devising new therapeutic
approaches. To better understand the contribution of
adrenomedullin (AM) to lung homeostasis, we built club
cell-specific conditional knockout (KO) mice for AM
and subjected them to naphthalene injury. Untreated KO
mice had lower levels of club cell 10 KDa protein
(CC10) immunoreactivity than their wild type (WT)
littermates in both terminal and regular bronchioles.
Naphthalene injury resulted in a rapid necrosis of club
cells followed by a progressive recovery of the
epithelium. Club cells proliferated at higher rates in the
KO mice and at 21 days post-injury the club cell
coverage of the main bronchioles was higher and more
homogeneous than in the WT animals. In conclusion, the
paracrine/autocrine influence of AM in club cells subtly
modulates their proliferation and spreading kinetics
during lung epithelium recovery.
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Citation
Histology and histopathology: Vol.31, nº6 (2016)
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