Publication: Review of renal oncocytosis (multiple oncocytic lesions) with focus on clinical and pathobiological aspects
Authors
Kuroda, Naoto ; Azusa, Tanaka ; Ohe, Chisato ; Mikami, Shuji ; Nagashima, Yoji ; Sasaki, Toyokazu ; Inoue, Keiji ; Hes, Ondrej ; Michal, Michal ; Brunelli, Matteo ; Martignoni, Guido
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Renal oncocytosis is a recently established
disease entity characterized by numerous oncocytic
tumors and diffuse involvement of oncocytic changes in
renal parenchymal epithelia. In this article, we review
this disease with a focus on its clinical and
pathobiological aspects. Clinically, renal oncocytosis
may occur in a sporadic form without any underlying
disease or may be associated with chronic renal
failure/long-term hemodialysis. However, Birt-Hogg-
Dubé syndrome, characterized by skin tumors such as
fibrofolliculoma or trichodiscoma, pulmonary lesions
including bullae and spontaneous pneumothorax, and
renal tumors should be evaluated in the differential
diagnosis. The disease can develop either unilaterally or
bilaterally. The involved renal parenchyma contains
several to multiple brownish-colored nodules of varying
size and is entirely replaced by lesions at the overt stage.
Histologically, oncocytic tumors in both the dominant
mass and smaller lesions encompass so-called hybrid
tumor, chromophobe renal cell carcinoma (RCC), and
renal oncocytoma (RO). Regarding renal parenchymal
abnormalities, infiltrative growth of oncocytic cells,
cortical cysts with oncocytic features, or extensive
oncocytic change in non-neoplastic tubules can also be
observed. Histochemical, immunohistochemical, and
molecular genetic features of chromophobe RCC and
RO arising in the setting of renal oncocytosis are
generally identical to those in the sporadic type.
However, hybrid tumors seem to be histologically distinct from chromophobe RCC and RO. In FISH
analyses of some hybrid tumors, a gain of chromosomes
1, 2, 6, 10, and 17 was identified. In one tumor, no germ
line mutation of folliculin gene was identified. Published
data show that tumors follow a benign course. Further
studies will be necesary to clarify the pathogenesis of renal oncocytosis.
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Citation
Histology and histopathology, Vol. 27, n.º 11 (2012)
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