Publication: Substance P and calcitonin gene-related peptide intrinsic choroidal neurons in human choroidal whole-mounts
Loading...
Date
2008
Authors
Hoz, Ana de ; Ramírez, Ana I. ; Salazar, Juan J. ; Rojas, Blanca ; Ramírez, José M. ; Triviño, Alberto
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
To determine the presence in the human
choroid of substance P (SP)-and calcitonin gene-related
peptide (CGRP) positive intrinsic choroidal neurons
(ICNs), choroidal whole-mounts were processed for
indirect immunofluorescence. An antibody to a
component of the neuronal cytoskeleton, neurofilament
200 kDa (NF-200), was combined with antibodies to SP
and to CGRP (neuropeptides proper to the sensory
nervous system). The human choroid possesses
numerous SP(+) and CGRP(+) ICNs. These neurons
were observed in the suprachoroid, both in isolation and
forming microganglia. For both types of ICNs studied,
neurons were more numerous in the temporal than in the
nasal regions. In both locations, SP(+) and CGRP(+)
ICNs were more abundant in the central choroid (the
choroid underneath the macular area of the retina), with
cell density diminishing outwards to the choroidal
periphery. There were no appreciable differences
between the two populations of ICNs studied in terms of
size, morphology or immunostaining characteristics. In
conclusion, given that peripheral sensory innervation
could be involved in the regulation of both choroidal
blood flow and vascular architecture, the SP(+) and
CGRP(+) ICNs described for the first time in the present
work may be involved in these mechanisms of vascular
regulation.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.