Publication: Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours
Authors
Al-Rawi, M.A.A. ; Mansel, R.E. ; Jiang, W.G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Interleukin-7 (IL-7) plays an important role
in the normal development and maintenance of the
human immune system. Its effects are mediated via its
receptor, IL-7R. Ligand-receptor engagement results in a
cascade of phosphorylation events mediated by various
molecules including the Janus kinases (Jak1 and Jak3),
PI3-kinase, Stats (signal transducers and activators of
transcription) and other molecules. The activation of IL-
7 signalling pathway results in survival, proliferation,
differentiation and maturation of haematopoietic cells
including B and T lymphocytes. Although the
relationship of IL-7 with the development and
differentiation of some haematological cancers like
leukaemias and lymphomas is well recognised, little is
known about it involvement with solid tumours. There
are several studies that have revealed IL-7/IL-7R
expression in epithelial systems and some human solid
epithelial tumours. Furthermore, IL-7 can be produced
by some human tumour cells and involved in tumour
development and progression. In this review article we
have summarised the main biological activities of IL-7
and its downstream signalling complex in relation to
some human solid malignancies.
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