Publication: Anagrelide does not exert a myelodysplastic effect on megakaryopoiesis: a comparative immunohistochemical
and morphometric study with hydroxyurea
Authors
Thiele, J. ; Kvasnicka, H.M. ; Ollig, S. ; Schmitt-Gräff, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
A comparative immunohistochemical and
morphometric study was performed on megakaryocytes
in 20 patients presenting with initial-early stage chronic
idiopathic myelofibrosis and accompanying
thrombocythemia to elucidate histological features
developing after hydroxyurea (HU) versus anagrelide
(ANA) therapy. Representative pre-and posttreatment
bone marrow biopsies were involved including the
monoclonal antibody CD61 for the identification of
precursor and mature stages of megakaryopoiesis. An
elaborate morphometric evaluation was in keeping with
a left-shifting showing a more frequent occurrence of
promegakaryoblasts and microforms in both therapy
groups. However, contrasting ANA, HU generated
defects of differentiation consistent with significant
dysplastic changes. In conclusion, concern about a
possible leukemogenic capacity following long-term HU
therapy is supported by our findings.
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