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Hypoxia-inducible factor (HIF) in human tumorigenesis

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dc.contributor.authorMabjeesh, N.J.es
dc.contributor.authorAmir, S.es
dc.date.accessioned2012-05-21T12:09:34Z
dc.date.available2012-05-21T12:09:34Z
dc.date.issued2007
dc.description.abstractHypoxia is a major event that occurs in most solid tumors. Intratumoral hypoxia is sufficient to activate the key transcription factor, hypoxia-inducible factor (HIF) that mediates the activation of the “survival machinery” in cancer cells. HIF can also be induced by oxygen-independent genetic alterations that activate a variety of oncogenic signaling pathways or inactivate tumor suppressors. Increased tumor HIF occurs at early stages of carcinogeniesis and is often correlated with increased angiogenesis, malignant progression, poor patient prognosis and chemoradio-resistance. HIF-a subunit, the oxygen-regulated subunit of HIF is overexpressed in a wide range of human solid tumors. Nuclear HIF-a protein immunostaining was restricted to tumor cells compared to normal tissues. Herein, we review and discuss the role of HIF in tumorigenesis and describe the overexpression of HIF-a proteins in human cancers and its association with overall clinical outcomeses
dc.formatapplication/pdfes
dc.format.extent14es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/27585
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectTumores
dc.subjectImmunohistochemistryes
dc.subject.other616.6 - Patología del sistema genitourinarioes
dc.titleHypoxia-inducible factor (HIF) in human tumorigenesises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.22, nº 5 (2007)