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Reduced innervation in the human pharynx in patients with obstructive sleep apnea

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dc.contributor.authorde Carlos, Félix
dc.contributor.authorCobo, Juan
dc.contributor.authorMacías, Emilio
dc.contributor.authorFeito, Jorge
dc.contributor.authorGonzález, Mónica
dc.contributor.authorCobo, Teresa
dc.contributor.authorFernández-Mondragón, María P.
dc.contributor.authorGarcía-Suárez, Olivia
dc.contributor.authorVega, José A.
dc.date.accessioned2020-09-30T06:55:15Z
dc.date.available2020-09-30T06:55:15Z
dc.date.issued2015
dc.description.abstractObstructive sleep apnea is a disease characterized by repetitive breathing during sleep that lead to reduced oxygen saturation and sleep disturbance among other symptoms. Obstructive sleep apnea is caused by blockade of the upper respiratory airway, although the pathogenic mechanism underlying this occlusion remains unknown. In these studies we explored the hypothesis that alterations in the innervation, especially mechanosensory innervation, of the pharynx may contribute to obstructive sleep apnea. We tested this hypothesis by analyzing the innervation of the human pharynx in normal individuals and in subjects clinically diagnosed with obstructive sleep apnea. Using immunohistochemistry for axon and Schwann cells, as well as for two putative mechanoproteins (ASIC2 and TRPV4), we observed a significant reduction in the density of nerve fibers in the submucosa of patients with obstructive sleep apnea as well as morphological abnormalities in mechanosensory corpuscles. Importantly, while ASIC2 and TRPV4 expression was regularly found in the axons of mechanosensory corpuscles distributed throughout the muscular layer in the control subjects, it was absent in patients with obstructive sleep apnea. These findings support that neurological alterations are important contributors to the pathogenesis of obstructive sleep apnea.es
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dc.format.extent10es
dc.identifier.citationHistology and Histopathology, vol.30, nº 7, (2015)
dc.identifier.doi10.14670/HH-11-593
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/96761
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectUpper airwayses
dc.subjectNerve fibreses
dc.subjectMechanosensory innervationes
dc.subjectMechanoproteinses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleReduced innervation in the human pharynx in patients with obstructive sleep apneaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30, nº7 (2015)